Articles

The randomized, placebo-controlled, phase 3 EXTENTORCH trial (NCT04012606) assessed the clinical efficacy and safety of the anti–PD-1 antibody toripalimab in combination with etoposide plus platinum-based chemotherapy for the first-line treatment of patients with extended-stage SCLC (ES-SCLC); initial results of this study, presented at the 2023 ESMO annual meeting, are summarized here. Read More ›

New immunotherapeutic approaches are being investigated in small cell lung cancer (SCLC). Tarlatamab is a bispecific T-cell engager that binds to both delta-like ligand 3 (DLL3) on SCLC cells and CD3 on T cells to elicit T-cell–mediated tumor lysis. Read More ›

An ongoing phase 2 study is evaluating HER2/HER3-directed  dendritic cell vaccines combined with pembrolizumab in patients with brain metastasis from triple-negative breast cancer or HER2-positive breast cancer. Read More ›

Preliminary results of the phase 2 NATASHA trial showed that neoadjuvant HER2-directed intratumoral dendritic cell vaccine therapy followed by paclitaxel, trastuzumab, and pertuzumab was well-tolerated in patients with HER2-positive breast cancer. Read More ›

The phase 1b/2 UCLA B-13 trial is evaluating the safety and efficacy of HER2 tyrosine kinase inhibitor tucatinib plus the cyclin-dependent kinase 4/6 inhibitor ribociclib and trastuzumab in the neoadjuvant setting for the treatment of patients with HER2-positive breast cancer. Read More ›

Results of the phase 2 PLEASURABLE study indicated that the chemotherapy-sparing regimen of dalpiciclib combined with pyrotinib and endocrine therapy showed significant antitumor activity for patients with estrogen receptor–positive/HER2-positive metastatic breast cancer in the front-line setting. Read More ›

Promising safety and antitumor activity data were obtained with the HER2 inhibitor ZN-1041, which is specifically designed to cross the blood-brain barrier, in preclinical and phase 1 studies in patients with HER2-positive breast cancer with brain metastases. Read More ›

Updated results of a phase 1b/2 trial showed that zanidatamab plus docetaxel as first-line therapy had a manageable safety profile and demonstrated promising antitumor activity in patients with advanced HER2-positive breast cancer. Read More ›

Real-world data from a US claims database reported similar efficacy as from a previous clinical trial in patients with previously treated HER2-positive metastatic breast cancer. Read More ›

Final results of the phase 2 ICU trial confirmed earlier reports of promising efficacy and acceptable safety of anti-HER2 antibody inetetamab in combination with camrelizumab and utidelone in patients with pretreated HER2-positive metastatic breast cancer. Read More ›