The European Hematology Association (EHA)

The European Hematology Association (EHA) is a non-governmental and not-for-profit membership organization that is guided by its mission to promote excellence in patient care, research, and education in hematology.
Somatic mutations affecting isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) genes are found in 15% to 20% of patients with acute myeloid leukemia (AML), with incidence increasing in older patients. These mutated enzymes represent therapeutic targets, and selective inhibitors of IDH1 and IDH2 are in early-phase development. This study assessed differences in outcomes for patients with relapsed AML and IDH1/IDH2 mutations. Read More ›

Anthracycline and Ara-C have been standard induction agents for acute myeloid leukemia (AML) for 30 years. Several trials comparing 90 mg/m2 of daunorubicin with 45 mg/m2 have found either overall benefits or benefit in specific patient subgroups, such as FLT3-ITD–mutant patients. This analysis confirms the value of higher-dose daunorubicin after a median follow-up of 2+ years. Read More ›

Inotuzumab ozogamicin (InO), a humanized anti-CD22 antibody conjugated to calicheamicin, has demonstrated superior responses compared with chemotherapy in patients with relapsed and refractory acute lymphoblastic leukemia (ALL) in a phase 3 trial known as INO-VATE. In this late-breaking presentation, researchers report overall survival and progression-free survival findings for InO relative to chemotherapy. Read More ›

Chimeric antigen receptor (CAR)-modified T cells are emerging as an effective and safe therapy for children and young adults with acute lymphoblastic leukemia (ALL). This study assesses CD19 CAR T cells in pediatric patients with ALL, including patients with a history of central nervous system (CNS) involvement. Read More ›

Ibrutinib, an inhibitor of Bruton’s tyrosine kinase, is approved for use as monotherapy in patients with treatment-naïve and relapsed chronic lymphocytic leukemia (CLL). Studies of ibrutinib in combination with other agents are underway. Follow-up data from a large phase 3 study of ibrutinib + BR versus BR in relapsed CLL have now reached the 2-year point. Read More ›

Acalabrutinib is a second-generation inhibitor of Bruton’s tyrosine kinase (BTK) that is currently being evaluated in patients with previously untreated and relapsed chronic lymphocytic leukemia (CLL), as well as other hematologic malignancies. Researchers report phase 1/2 study results for acalabrutinib, including overall response rates, rates of treatment-related lymphocytosis, bleeding risk, and other safety details. Read More ›

Patients with deletion 17p chronic lymphocytic leukemia (CLL) have aggressive disease and poor outcomes with chemoimmunotherapy. Ibrutinib, a once-daily therapy that inhibits Bruton’s tyrosine kinase, is approved for previously untreated patients with CLL, including patients with deletion 17p. This cross-study analysis of efficacy and tolerability outcomes for ibrutinib reports 2+-year data in this high-risk subset of patients. Read More ›

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