Methicillin-resistant Staphylococcus aureus is quite often a causative pathogen in acute bacterial skin and skin structure infections (ABSSSIs), and the infections may be mono- or polymicrobial, with Gram-negative pathogens present.1 In OASIS-1, patients with ABSSSI were treated with intravenous (IV) omadacycline (OMC) or linezolid (LZD), with a possible transition to oral formulation after at least 3 days of IV therapy. OASIS-2 investigated oral-only OMC.
A total of 691 patients receiving OMC and 689 patients receiving LZD were included. Patients in integrated OMC and LZD groups had similar baseline characteristics. The mean age of patients was 45 years, 64% were male, and 83% were enrolled at US sites. Early clinical response in the modified intention-to-treat (mITT) group was the primary end point in both studies and was defined as a ≥20% reduction in lesion size at 48 to 72 hours after treatment initiation. The secondary end point was investigator assessment of clinical response at post-therapy evaluation in the mITT and clinically evaluable populations, 7 to 14 days after treatment initiation.2
Results showed the following2:
The integrated analysis of OASIS-1 and OASIS-2 showed IV and oral OMC to be a safe and effective treatment option for ABSSSI that was generally well-tolerated in patients.