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San Antonio Breast Cancer Symposium (SABCS)
SABCS 2022
PIK3CA-Mutated Breast Cancer
PIK3CA-Mutated Breast Cancer
Assessing the Activity of Alpelisib in Pathogenic Breast Cancer Mutations Utilizing Patient-Derived Xenografts
SABCS 2022
In vitro study finds combination approaches with alpelisib in triple-negative breast cancer harboring PIK3CA mutations provide synergistic effect.
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PIK3CA-Mutated Breast Cancer
Trial to Assess Alpelisib in Combination with Fulvestrant in PIK3CA-Mutated HR-Positive/HER2-Negative Advanced Breast Cancer
SABCS 2022
Clinical trial assessing the additive benefit of alpelisib to fulvestrant in treatment-refractory HR-positive/HER2-negative ABC currently enrolling patients.
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PIK3CA-Mutated Breast Cancer
Assessing the Additive Benefit of Alpelisib to Fulvestrant in Advanced Breast Cancer Across the Gene Mutation Landscape: Findings from a Post Hoc Analysis of the SOLAR-1 Trial
SABCS 2022
Results from the SOLAR-1 study demonstrate that only PIK3CA mutations can predict sensitivity to alpelisib in patients with HR-positive/HER2-negative breast cancer.
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PIK3CA-Mutated Breast Cancer
Long-Term Disease Control with Fulvestrant plus Alpelisib in PIK3CA-Mutated HR-Positive/HER2-Negative Advanced Breast Cancer: Findings from Cohort A of the BYLieve Study
SABCS 2022
Findings from Cohort A of the BYLieve study suggest that treatment of HR-positive/HER2-negative breast cancer with PIK3CA mutation drivers with alpelisib plus fulvestrant may lead to long-term disease control.
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PIK3CA-Mutated Breast Cancer
Trial to Assess Alpelisib in Combination with Tucatinib in PIK3CA-Mutated HER2-Positive Metastatic Breast Cancer
SABCS 2022
Clinical trial assessing alpelisib plus tucatinib in HER2-positive mBC with PIK3CA mutations is currently enrolling patients.
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Year in Review / Wrap-Ups
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