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Canakinumab Combined with First-Line Pembrolizumab and Chemotherapy for Advanced NSCLC: CANOPY-1
NSCLC IO 2022 - Midyear Review
The combination of canakinumab and pembrolizumab plus chemotherapy did not statistically improve efficacy as first-line treatment in patients with advanced NSCLC.
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Year in Review
Neoadjuvant Durvalumab Alone or Combined with Novel Agents for Resectable, Early-Stage NSCLC: NeoCOAST Trial
NSCLC IO 2022 - Midyear Review
Neoadjuvant treatment of patients with resectable early-stage NSCLC with durvalumab in combination with the anti-CD73 monoclonal antibody oleclumab, the anti-NKG2A monoclonal antibody monalizumab, or the anti-STAT3 antisense oligonucleotide danvatirsen resulted in improved efficacy compared with durvalumab alone.
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Year in Review
Neoadjuvant Nivolumab and Platinum-Doublet Chemotherapy for Resectable NSCLC: CheckMate 816
NSCLC IO 2022 - Midyear Review
Neoadjuvant nivolumab plus platinum-doublet chemotherapy resulted in clinically meaningful improvement in event-free survival and pathologic complete response in patients with resectable NSCLC compared with chemotherapy alone.
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Year in Review
MEDI5752, a Novel PD-1/CTLA-4 Bispecific Checkpoint Inhibitor for Advanced Solid Tumors: First-in-Human Study
NSCLC IO 2022 - Midyear Review
MEDI5752, a novel PD-1/CTLA-4 bispecific checkpoint inhibitor, showed promising antitumor activity and durable clinical benefit and was tolerated at doses 1500 mg.
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Year in Review
Analysis of Serum Protein Levels for Biomarker-Guided Therapy with Nivolumab with or without Ipilimumab in Patients with Squamous-Cell Lung Cancer: The SWOG Lung-MAP S1400I Trial
NSCLC IO 2022 - Midyear Review
Analysis of the changes in blood circulating soluble proteins resulted in identifying potential response biomarkers to immune checkpoint inhibitors in patients with squamous-cell lung cancer.
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Year in Review
Camrelizumab Combined with Apatinib and Albumin Paclitaxel in Advanced Nonsquamous NSCLC: CAPAP-Lung Phase 2 Study
NSCLC IO 2022 - Midyear Review
Camrelizumab plus albumin paclitaxel and apatinib resulted in promising antitumor activity with an acceptable safety profile for first-line treatment of advanced NSCLC.
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Year in Review
First-Line Treatment of Metastatic NSCLC with Durvalumab with or without Tremelimumab in Combination with Chemotherapy: AE Management in the POSEIDON Trial
NSCLC IO 2022 - Midyear Review
The safety profile of durvalumab ± tremelimumab plus chemotherapy was manageable, but with more immune-related adverse events observed with durvalumab and tremelimumab.
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Year in Review
Resistance Biomarkers to PD-1/PD-L1–Targeted Immune Checkpoint Inhibitors: The PIONeeR Trial
NSCLC IO 2022 - Midyear Review
The PIONeeR trial identified 37 biomarkers that could predict resistance to anti–PD-1/PD-L1 therapy before treatment initiation.
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Year in Review
First-Line Nivolumab plus Ipilimumab in Combination with Chemotherapy versus Chemotherapy Alone in Patients with Metastatic NSCLC: 3-Year Update from CheckMate 9LA
NSCLC IO 2022 - Midyear Review
The 3-year extended follow-up of CheckMate 9LA demonstrated that first-line nivolumab plus ipilimumab in combination with limited chemotherapy resulted in long-term, durable clinical benefit compared with chemotherapy alone in patients with metastatic NSCLC, regardless of PD-L1 mutation status.
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Year in Review
Phase 2 Study of Nivolumab plus Ipilimumab in Metastatic Uveal Melanoma
Dual IO 2021 - Year in Review
Nivolumab plus ipilimumab demonstrates deep and sustained confirmed responses for patients with metastatic uveal melanoma.
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