American Society of Hematology (ASH)

The American Society of Hematology (ASH) is a professional organization representing hematologists. It was founded in 1958. Its annual meeting is held in December of every year and has attracted more than 30,000 attendees. The society publishes the medical journal Blood, the most cited peer-reviewed publication in the field, which is available weekly in print and online, as well as the newly launched, online, peer-reviewed open-access journal, Blood Advances.
Results of the phase 2 CLL2-BZAG trial indicated that MRD-guided triple combination of zanubrutinib, venetoclax, and obinutuzumab induced deep remissions in patients with R/R CLL including those previously treated with BTKi and/or venetoclax. Read More ›

Final data from the phase 3 MURANO trial demonstrated a significantly prolonged time to second progression-free survival event in the venetoclax/rituximab arm, with high response rates achieved even by patients who subsequently received retreatment or crossed over to venetoclax-based regimens or BTKi therapy. Read More ›

Biomarker subgroup analysis results indicate that zanubrutinib treatment was associated with superior PFS in all biomarker subgroups analyzed compared to bendamustine/rituximab in treatment-naïve patients with CLL/SLL without del(17p). Read More ›

Results of the phase 1/2 BRUIN study indicate that fixed-duration pirtobrutinib combined with venetoclax ± rituximab was well tolerated and showed promising efficacy in patients with relapsed or refractory chronic lymphocytic leukemia. Read More ›

Results of a phase 2 study suggests that the highly selective Bruton tyrosine kinase inhibitor TL-895 therapy led to rapid bone marrow clearance of leukemic cells to induce deeper and more durable responses, with a favorable adverse event profile in patients with treatment-naïve and relapsed/refractory CLL/SLL. Read More ›

Extended follow-up results of the ELEVATE-TN trial (median follow-up of 74.5 months) confirmed sustained efficacy and safety of acalabrutinib/obinutuzumab and acalabrutinib monotherapy compared to obinutuzumab/chlorambucil in patients with treatment-naïve CLL, including in patients with high-risk genetic features. Read More ›

Results of the UK FLAIR Study indicate that MRD-guided treatment duration of Ibrutinib+ venetoclax significantly improved survival outcomes compared to FCR in untreated chronic lymphocytic leukemia. Read More ›

Longer follow-up data of the GLOW study indicate that fixed-duration ibrutinib + venetoclax shows sustained PFS superiority versus chemoimmunotherapy in patients with previously untreated CLL. Read More ›

Updated results of the CAPTIVATE study show promising efficacy with ibrutinib-based retreatment in patients progressing on a first-line, fixed duration ibrutinib + venetoclax regimen. Read More ›

Longer follow-up data of the TRANSCEND CLL 004 trial indicated that lisocabtagene maraleucel continued to demonstrate durable CR/CRi and high uMRD rates in patients with heavily pretreated, high-risk R/R CLL/SLL; no new safety signals emerged. Read More ›

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