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The European Hematology Association (EHA)
EHA 2016 – Leukemia
EHA 2016 – Leukemia
Innovative Therapies in CLL: Saturday, June 11
EHA 2016
,
EHA 2016 – Leukemia
Developments in chronic lymphocytic leukemia (CLL) continue to move at a rapid pace. New agents show deep and durable responses in relapsed and treatment-naïve patients. This session includes reports of large clinical trials that demonstrate durable activity and safety of targeted agents for CLL.
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Reduced-Intensity Conditioning (RIC) Allogeneic Hematopoietic Stem-Cell Transplantation for De Novo ALL in Adults
EHA 2016
,
EHA 2016 – Leukemia
Allogeneic hematopoietic stem-cell transplantation (alloHSCT) is a potentially curable treatment modality for adults with acute lymphoblastic leukemia (ALL), offering significant improvement in survival and reduction in relapse incidence. This approach is limited, however, by toxicity and early mortality. Researchers report outcomes of patients who received RIC followed by alloHSCT in the UKALL14 trial.
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Response-Adapted Sequential Azacitidine and Intensive Chemotherapy Is Effective in Patients Aged >60 Years with Newly Diagnosed AML
EHA 2016
,
EHA 2016 – Leukemia
Treatment options for acute myeloid leukemia (AML) in patients aged >60 years include intensive chemotherapy (IC) and azacitidine (AZA). The multicenter RAS-AZIC study of the East German Study Group (OSHO), evaluated first-line treatment with AZA followed by AZA or IC in these patients. Data from the planned interim analysis are presented.
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Outcomes Associated with Conventional Salvage Therapy in Patients with Refractory or Relapsed AML and IDH1/IDH2 Mutations
EHA 2016
,
EHA 2016 – Leukemia
Somatic mutations affecting isocitrate dehydrogenase 1 (
IDH1
) or 2 (
IDH2
) genes are found in 15% to 20% of patients with acute myeloid leukemia (AML), with incidence increasing in older patients. These mutated enzymes represent therapeutic targets, and selective inhibitors of
IDH1
and
IDH2
are in early-phase development. This study assessed differences in outcomes for patients with relapsed AML and
IDH1/IDH2
mutations.
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Higher-Dose Daunorubicin Is Effective in Patients with AML Who Harbor FLT3-ITD Mutations
EHA 2016
,
EHA 2016 – Leukemia
Anthracycline and Ara-C have been standard induction agents for acute myeloid leukemia (AML) for 30 years. Several trials comparing 90 mg/m
2
of daunorubicin with 45 mg/m
2
have found either overall benefits or benefit in specific patient subgroups, such as
FLT3-ITD
–mutant patients. This analysis confirms the value of higher-dose daunorubicin after a median follow-up of 2+ years.
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Overall Survival Benefit in Relapsed and Refractory B-Cell ALL Patients Receiving Inotuzumab Ozogamicin
EHA 2016
,
EHA 2016 – Leukemia
Inotuzumab ozogamicin (InO), a humanized anti-CD22 antibody conjugated to calicheamicin, has demonstrated superior responses compared with chemotherapy in patients with relapsed and refractory acute lymphoblastic leukemia (ALL) in a phase 3 trial known as INO-VATE. In this late-breaking presentation, researchers report overall survival and progression-free survival findings for InO relative to chemotherapy.
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CD19 CAR T Cells Induce Potent Responses and Control CNS Leukemia in Relapsed ALL
EHA 2016
,
EHA 2016 – Leukemia
Chimeric antigen receptor (CAR)-modified T cells are emerging as an effective and safe therapy for children and young adults with acute lymphoblastic leukemia (ALL). This study assesses CD19 CAR T cells in pediatric patients with ALL, including patients with a history of central nervous system (CNS) involvement.
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Ibrutinib plus Bendamustine and Rituximab (BR) in Previously Treated CLL/SLL: 2-Year Follow-Up Data from the HELIOS Study
EHA 2016
,
EHA 2016 – Leukemia
Ibrutinib, an inhibitor of Bruton’s tyrosine kinase, is approved for use as monotherapy in patients with treatment-naïve and relapsed chronic lymphocytic leukemia (CLL). Studies of ibrutinib in combination with other agents are underway. Follow-up data from a large phase 3 study of ibrutinib + BR versus BR in relapsed CLL have now reached the 2-year point.
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Acalabrutinib, a Second-Generation BTK Inhibitor, Is Active in Previously Untreated CLL
EHA 2016
,
EHA 2016 – Leukemia
Acalabrutinib is a second-generation inhibitor of Bruton’s tyrosine kinase (BTK) that is currently being evaluated in patients with previously untreated and relapsed chronic lymphocytic leukemia (CLL), as well as other hematologic malignancies. Researchers report phase 1/2 study results for acalabrutinib, including overall response rates, rates of treatment-related lymphocytosis, bleeding risk, and other safety details.
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