European Society for Medical Oncology (ESMO)

The European Society for Medical Oncology (ESMO) is the leading professional organisation for medical oncology. With more than 25,000 members representing oncology professionals from over 150 countries worldwide, ESMO was founded in 1975.
Interim results from a phase 1/2 study that evaluated the clinical safety and efficacy of HPN328, a trispecific, delta-like canonical Notch ligand 3 (DLL3)–targeting T-cell engager, in patients with small cell lung cancer (SCLC) and other neuroendocrine neoplasms (NENs) was presented at the 2023 ESMO annual meeting. Read More ›

Based on improvements in survival outcomes with a PD-1/PD-L1 inhibitor in combination with chemotherapy in patients with extensive-stage small cell lung cancer (SCLC), a nonrandomized, single-center, phase 2 study (LungMate-005; NCT04539977) was conducted to explore the clinical safety and efficacy of neoadjuvant PD-L1 inhibitor TQB2450 plus chemotherapy induction therapy followed by surgery or radiotherapy in patients with limited-stage small-cell lung cancer (LS-SCLC). Read More ›

The majority of patients with small cell lung cancer (SCLC) present with extensive-stage disease, which is associated with poor prognosis. Read More ›

Atezolizumab plus carboplatin/etoposide is indicated for the first-line treatment of extensive-stage small cell lung cancer (ES-SCLC) based on results of the pivotal phase 3 IMpower133 trial. Read More ›

Phase 1 results of the prospective, open-label, uncontrolled, multicenter, phase 1/2 LUPER study (NCT04358237) indicated that the lurbinectedin plus the anti–PD-1 pembrolizumab combination regimen showed promising antitumor activity with a manageable safety profile in patients with relapsed small cell lung cancer (SCLC) and established the recommended phase 2 dose (RP2D) of lurbinectedin + pembrolizumab. Read More ›

Extensive-stage small cell lung cancer (ES-SCLC) is often treated with a combination of immunotherapy and chemotherapy; however, limited treatment options are available following progression on this combination regimen, underscoring the need for novel therapies in the second-line setting. Read More ›

The randomized, placebo-controlled, phase 3 EXTENTORCH trial (NCT04012606) assessed the clinical efficacy and safety of the anti–PD-1 antibody toripalimab in combination with etoposide plus platinum-based chemotherapy for the first-line treatment of patients with extended-stage SCLC (ES-SCLC); initial results of this study, presented at the 2023 ESMO annual meeting, are summarized here. Read More ›

New immunotherapeutic approaches are being investigated in small cell lung cancer (SCLC). Tarlatamab is a bispecific T-cell engager that binds to both delta-like ligand 3 (DLL3) on SCLC cells and CD3 on T cells to elicit T-cell–mediated tumor lysis. Read More ›

A phase 3 study comparing nivolumab to treatment with gemcitabine or pegylated liposomal doxorubicin for patients with platinum-resistant ovarian cancer revealed similar overall survival and response rates between the 2 groups. Nivolumab was better tolerated than gemcitabine/pegylated liposomal doxorubicin, with fewer all-grade and grade 3/4 adverse events. Read More ›

A groundbreaking report presented today at ESMO conveyed data from an interim analysis of a phase 2b trial demonstrating that the combination of NPS + trastuzumab is safe and may provide clinically meaningful benefit to women with HER2 low-expressing breast cancer, with a particularly marked benefit in the subgroup with triple-negative breast cancer. Read More ›

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